Ultrafast imaging technologies are essential to capture transient phenomena in biology, physics, and chemistry. Currently, various pump-probe approaches are the mainstream in ultrafast imaging. However, these schemes require the targeted phenomena to be precisely repetitive and thus are inapplicable in imaging many single-event ultrafast phenomena, such as optical rogue waves, nuclear explosions, and scattering in dynamic biological tissue.
Compressed ultrafast photography (CUP), as a single-shot ultrafast computational imaging modality, overcomes this limitation. Synergistically combining compressed sensing and streak imaging, CUP can image non-repetitive transient events at 100 billion frames per second. In addition, akin to conventional photography, CUP is receive-only. Avoiding specialized active illumination, CUP is perfectly suited to imaging a variety of luminescent processes, such as fluorescence and scattering.
Using CUP, we have visualized many light-speed phenomena in real time, including reflection and refraction of a single laser pulse, photon racing in two different media, and faster-than-light propagation of non-information. Very recently, we have made the first-ever real-time video recording of a scattering-induced photonic Mach cone — the optical counterpart of the sonic Mach cone or sonic boom produced by a supersonic jet.
CUP has found applications in fluorescence imaging and metrology. First, by integrating CUP with a color separation unit, we have demonstrated 2D fluorescent light time mapping. Thus, CUP can be readily applied in single-shot fluorescence lifetime microscopy (FLIM). In addition, by employing a short-pulsed laser with CUP, we have demonstrated single-shot encrypted volumetric imaging by measuring the time-of-flight light signal back scattered from 3D objects.
Given the capability of CUP, we expect it to find widespread applications in both fundamental and applied sciences.
Selected Media Coverage
May, 2020 Yahoo/Popular Mechanics: The World's Fastest Camera is Frankly Mind-Boggling
For as much as cameras allow us to experience phenomena that would otherwise go unnoticed, their imaging speeds still fundamentally limit our capability to see, well, everything. Now, scientists at the California Institute of Technology hope to change that... More>>
New camera technology that takes up to 1 trillion frames per second is so advanced it can take images of transparent phenomena, U.S. researchers say. The camera builds on previous research, in which the team used the technology to capture light traveling in slow motion... More>>
March, 2019 Planet Slow Mo: Filming the Speed of Light at 10 Trillion FPS
March, 2019 Planet Slow Mo: How Do You Film the Speed of Light?
July, 2016 Scientific American: Light-Speed Camera Captures Split-Second Action
A new approach to high-speed photography could help capture the clearest-ever footage of light pulses, explosions or neurons firing in the brain, according to a team of ultrafast camera developers... More>>
January, 2015 Fortune Magazine Coverage: Smile! You're on the World's Quickest 2-D Camera
Researchers have created the fastest imaging device of its type—a tool that may transform biomedicine, telecommunications, and more... More>>
January, 2015 the Voice of America: New Ultrafast Camera could Help Turn Sci-fi into Reality
Biomedical engineer Lihong Wang and his research lab at Washington University in St. Louis have invented or discovered a whole bunch of high-tech imaging techniques, with sophisticated names like functional photoacoustic tomography, dark-field confocal photoacoustic microscopy and time-reversed ultrasonically encoded optical focusing... More>>
Selected Publications
- [Wang, P.; Mishra, Y. N.; Bauer, F. J.]; Gudipati, M. S.; Wang, L. V.; "Single-shot two-dimensional nano-size mapping of fluorescent molecules by ultrafast polarization anisotropy imaging," Nature Communications 16(1) (2025) [PDF]
- [Zhang, Y.; Shen, B.]; Wu, T.; Zhao, J.; Jing, J. C.; Wang, P.; Sasaki-Capela, K.; Dunphy, W. G.; Garrett, D.; Maslov, K.; Wang, W.; Wang, L. V.; "Ultrafast and hypersensitive phase imaging of propagating internodal current flows in myelinated axons and electromagnetic pulses in dielectrics," Nature Communications 13(1) 5247 (2022) [PDF]
- [L. Fan; X. Yan]; H. Wang; L. V. Wang; "Real-time observation and control of optical chaos," Science Advances 7(3) eabc8448 (2021) [PDF]
- [Liang, J.; Wang, P.]; Zhu, L.; Wang, L. V.; "Single-shot stereo-polarimetric compressed ultrafast photography for light-speed observation of high-dimensional optical transients with picosecond resolution," Nature Communications 11(1) 5252 (2020) [PDF]
- Wang, P.; Liang, J.; Wang, L. V.; "Single-shot ultrafast imaging attaining 70 trillion frames per second," Nature Communications 11(1) 2091 (2020) [PDF]
- [Jing, J. C.; Wei, X.]; Wang, L. V.; "Spatio-temporal-spectral imaging of non-repeatable dissipative soliton dynamics," Nature Communications 11(1) 2059 (2020) [PDF]
- Kim, T.; Liang, J.; Zhu, L.; Wang, L. V.; "Picosecond-resolution phase-sensitive imaging of transparent objects in a single shot," Science Advances 6(3) eaay6200 (2020) [PDF]
- Liang, J. Y.; Wang, L. H. W.; "Single-shot ultrafast optical imaging," Optica 5(9) 1113-1127 (2018) [PDF]
- Liang, J. Y.; Zhu, L. R.; Wang, L. V.; "Single-shot real-time femtosecond imaging of temporal focusing," Light-Science & Applications 7(1) 42 (2018) [PDF]
- [Liang, J.; Ma, C.; Zhu, L.]; Chen, Y.; Gao, L.; Wang, L. V.; "Single-shot real-time video recording of a photonic Mach cone induced by a scattered light pulse," Science Advances 3(1) e1601814 (2017) [PDF]
- [Zhu, L.; Chen, J.; Liang, J.]; Xu, Q.; Gao, L.; Ma, C.; Wang, L. V.; "Space- and intensity-constrained reconstruction for compressed ultrafast photography," Optica 3(7) 694-697 (2016) [PDF]
- Liang, J.; Gao, L.; Hai, P.; Li, C.; Wang, L. V.; "Encrypted three-dimensional dynamic imaging using snapshot time-of-flight compressed ultrafast photography," Scientific Reports 5(15504) 1-10 (2015) [PDF]
- [Gao, L.; Liang, J.]; Li, C.; Wang, L. V.; "Single-shot compressed ultrafast photography at one hundred billion frames per second," Nature 516(7529) 74-77 (2014) [PDF]